A RETROSPECTIVE EVALUATION OF ADVERSE REACTIONS TO TRIMETHOPRIM-SULFONAMIDE COMBINATIONS IN DOGS AND CATS

Adverse reactions to various trimethoprim-sulphonamide (T-S) combinati ons were studied retrospectively in dogs and cats referred to the Utre cht University Department of Clinical Sciences of Companion Animals du ring the period 1985-1994. Dermatological and systemic reactions were observed in 19 dogs and 2 cats. Specific histological reaction pattern s were seen in 3 dogs with toxic epidermal necrolysis, in 1 dog and 1 cat with erythema multiforme, and in 1 dog with pemphigus foliaceus. D iagnostic criteria used in humans proved to be reliable in dogs and ca ts as well. Adverse reactions were observed within 7-14 days after adm inistration and were most often due to sulphadiazine (76%) and sulphat roxazole (14%), The incidence of adverse reactions to T-S was 0.25%.