CASE OF ANGIOCENTRIC T-CELL LYMPHOMA PRESENTING AS LETHAL MIDLINE GRANULOMA

A case of angiocentric T-cell lymphoma with glabellar skin being the o nly affected site was reported. A 43-year-old woman had a several mont hs' history of glabellar swelling followed by progressive and destruct ive ulceration of the region, Histopathology of the biopsied specimen showed panniculitis with atypical lymphocytes and degenerative vessels filled with atypical cells. Most of the infiltrated lymphocytes were positive for CD2, CD3, CD4 and CD5. Antibodies to Epstein-Barr virus w ere detected in the patient serum, Intensive chemotherapy using a prot ocol of the L17M regimen was partially effective for clinical manifest ations. Angiocentric T-cell lymphoma presenting as lethal midline gran uloma is a rare but distinct entity with an acute fatal course.