EFFICACY AND TOLERANCE OF ONCE-DAILY QUINAPRIL IN MILD-TO-MODERATE ARTERIAL-HYPERTENSION - EFFICACY EVALUATED BY A 24-HOUR MONITORING OF ARTERIAL BLOOD-PRESSURE

We evaluated the efficacy and tolerance of a single daily dose of quin april in 10 patients with mild to moderate arterial hypertension. Pati ents were treated for 12 weeks after a 2-week placebo run-in period. 2 4-hour monitoring of arterial pressure was performed the day before in clusion and after treatment for 12 weeks. Standing and sitting blood p ressures were measured at the end of the 4th, 8th and 12th weeks. Pres sures recorded during 24-hour monitoring showed a significant reductio n of systolic, diastolic and mean arterial pressures. A significant de crease in blood pressure was seen after 4 weeks' treatment and persist ed until the end of the trial, Heart rate remained unchanged throughou t the study. Biological parameters did not change. No adverse effects were reported and there were no changes in laboratory tests. Tolerance may be considered excellent.