Because people now spend nearly 100% of their time indoors and because
of changes in building ventilation and emissions over the last 100 ye
ars, there has been growing interest of the public and science on indo
or air quality and climate and its influence on human health. While kn
owledge on some indoor-related illnesses exists, many questions still
remain regarding a complex of unspecific symptoms mostly found in air
conditioned office buildings. This complex of symptoms, called sick bu
ilding syndrome (SBS), is characterized by skin and mucous membrane as
well as central nervous system symptoms. Extensive epidemiological re
search in recent years has shown different causes, but there has been
little effort towards understanding the basic mechanisms of SBS. Inten
sified experimental-epidemiological research will be necessary to avoi
d health complaints and economic costs. The annual cost due to illness
and loss of productivity from SBS in the U.S. has been estimated to b
e $55 billion for commercial buildings.