CHARACTERISTICS OF CLONED CEREBROVASCULAR ENDOTHELIAL-CELLS FOLLOWINGINFECTION WITH THEILERS VIRUS .1. ACUTE INFECTION

Authors
WELSH CJR SAPATINO BV ROSENBAUM BA SMITH R
Citation
Cjr. Welsh et al., CHARACTERISTICS OF CLONED CEREBROVASCULAR ENDOTHELIAL-CELLS FOLLOWINGINFECTION WITH THEILERS VIRUS .1. ACUTE INFECTION, Journal of neuroimmunology, 62(2), 1995, pp. 119-125
Citations number
41
Categorie Soggetti
Neurosciences,Immunology
Journal title
Journal of neuroimmunology → ACNP
ISSN journal
01655728
Volume
62
Issue
2
Year of publication
1995
Pages
119 - 125
Database
ISI
SICI code
0165-5728(1995)62:2<119:COCCEF>2.0.ZU;2-N
Abstract
The present study describes the replication of Theiler's virus in clon ed cerebrovascular endothelial cells (CVE) isolated from strains of mi ce that are either susceptible or resistant to Theiler's virus-induced demyelination (TVID). CVE isolated from all strains of mice were equa lly permissive to Theiler's virus infection. Interferon-gamma and tumo r necrosis factor-alpha were found to inhibit the replication of Theil er's virus in CVE. A correlation between susceptibility to demyelinati on and the ability of Theiler's virus to induce MHC Class I on CVE was demonstrated.