NITRILOTRIACETAMIDE - SYNTHESIS IN CONCENTRATED SULFURIC-ACID AND STABILITY IN WATER

Authors
SMITH DA SUCHECK S CRAMER S BAKER D
Citation
Da. Smith et al., NITRILOTRIACETAMIDE - SYNTHESIS IN CONCENTRATED SULFURIC-ACID AND STABILITY IN WATER, Synthetic communications, 25(24), 1995, pp. 4123-4132
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
25
Issue
24
Year of publication
1995
Pages
4123 - 4132
Database
ISI
SICI code
0039-7911(1995)25:24<4123:N-SICS>2.0.ZU;2-Z
Abstract
Acid hydrolysis of N(CH2CN)(3) leads either nitrilotriacetamide, 1, an d/or 3,5-dioxopiperazineacetamide, 4, in quantitative yield. 1 slowly and cleanly converts to 3,5-dioxopiperazineacetic acid, 5, in water, a lthough ammonium salts prevent this reaction.