Dg. Peroni et al., DOUBLE-BLIND TRIAL OF HOUSE-DUST MITE IMMUNOTHERAPY IN ASTHMATIC-CHILDREN RESIDENT AT HIGH-ALTITUDE, Allergy, 50(11), 1995, pp. 925-930
Twenty-three Dermatophagoides pteronyssinus (Dpt)-sensitive asthmatic
children aged 7-14 years entered a double-blind, placebo-controlled tr
ial of standardized immunotherapy (IT) (Alpare) while resident at high
altitude. Dpt sensitivity was evaluated by skin prick tests at differ
ent allergen concentrations at the enrollment and after 6 and 12 month
s of treatment. Bronchial hyperreactivity was evaluated at the same ti
me points, and on each occasion, histamine challenge and, the followin
g day, Dpt bronchial challenge were performed. All patients, irrespect
ive of active treatment, improved clinically and in lung function with
increased PC20 and Dpt-PD20. Alpare-treated patients had a significan
tly decreased sensitivity on Dpt skin testing (P < 0.009) and felt tha
t their asthma had improved (P < 0.001) compared with placebo-treated
subjects, but there was no difference between the treatment groups in
lung function or bronchial challenge response. IT neither increased no
r decreased bronchial histamine sensitivity. Our results indicate that
Dpt IT benefits asthmatic children, but improvement by allergen avoid
ance at high altitude is even greater.