The Gushing syndrome during pregnancy is very infrequent, being even m
ore so that of hypophysary etiology despite corticotropic adenomas bei
ng more prevalent in fertile-aged women. Its diagnosis is difficult si
nce it may be confused with the physiologic alterations of the cortiso
l and the ACTH which occur during pregnancy, The treatment is controve
rsial, In the cases reported to date, pregnancy represented a worsenin
g of the picture, The case of a patient diagnosed with Gushing disease
during the first trimester of pregnancy is presented, The hypercortic
ism improved clinically and biochemically during the pregnancy with no
maternofetal complications observed, The disease activity continued f
ollowing delivery.