Background. Depression is a significant health problem in the United S
tates. This study examined the relationship between depression and sub
stance use, substance problems, conduct disorders, and sociodemographi
c factors in primary care settings. Methods. A survey of 1898 patients
in 88 primary care offices was conducted using a self-administered he
alth-habits questionnaire. Depression was assessed for both lifetime a
nd for the past 30 days using the Diagnostic and Statistical Manual of
Mental Disorders, Third Edition Revised (DSIM-III-R) criteria. Result
s. A total of 21.7% of women and 12.7% of men met DSM-III-R criteria f
or depression in the 30 days prior to completing the survey. Lifetime
rates of depression were 36.1% for women and 23.3% for men. Young wome
n who smoke, drink, or use marijuana, and both men and women with anti
social personality disorder and a family history of mental health prob
lems are particularly at high risk for depression. Conclusions. One in
5 women and one in 10 men who see their primary care physicians have
recently been depressed.