PERIPHERAL PRIMITIVE NEUROECTODERMAL TUMORS OF THE HEAD AND NECK

Objective: Primitive neuroectodermal tumor is a malignant small round cell tumor of neuroectodermal origin. The occurrence of these tumors i n the head and neck is rare. Our objective is to document the frequenc y of presentation, methods of diagnosis, and forms of treatment used t o combat primitive neuroectodermal tumors in the head and neck. Design : Retrospective chart review. Results: The most common location for pr imitive neuroectodermal tumors in our series was the thoracopulmonary region (46%); the next most common location was the head and neck (42% ). Metastatic disease was present in 31% of patients at the time of di agnosis. Cytogenic analysis was found to be helpful in confirming the diagnosis of primitive neuroectodermal tumor. Therapy for primitive ne uroectodermal tumors included surgery, chemotherapy, and radiation the rapy. Survival statistics were poor, with 65% of the patients alive at 2 years' follow-up. Conclusions: Primitive neuroectodermal tumor is a n aggressive malignant small round cell tumor that may present in the head and neck. Long-term survival for patients with primitive neuroect odermal tumor is still poor; however, the use of improved chemotherape utic agents combined with aggressive surgical control of primary disea se and, in some cases, radiation therapy should lead to improved long- term survival.