CLONING AND SEQUENCE-ANALYSIS OF THE CORYNEBACTERIUM-DIPHTHERIAE DTXRHOMOLOG FROM STREPTOMYCES-LIVIDANS AND S-PILOSUS ENCODING A PUTATIVE IRON REPRESSOR PROTEIN

The iron-regulated promoter involved in desferrioxamine B synthesis of Streptomyces pilosus contains a region homologous to the iron repress or (DtxR)-binding site of the diphtheria toxin gene promoter in Coryne bacterium diphtheriae [Gunter et al., J. Bacteriol. 175 (1993) 3295-33 02]. Here, we report the cloning and sequencing of the putative Strept omyces iron repressor gene, homologous to dtxR of C. diphtheriae. The N-terminal 139 amino acids of the deduced protein are 73% identical to DtxR.