STRUCTURAL STUDIES OF VINBLASTINE ALKALOIDS BY EXCITON COUPLED CIRCULAR-DICHROISM

Authors
DONG JG BORNMANN W NAKANISHI K BEROVA N
Citation
Jg. Dong et al., STRUCTURAL STUDIES OF VINBLASTINE ALKALOIDS BY EXCITON COUPLED CIRCULAR-DICHROISM, Phytochemistry, 40(6), 1995, pp. 1821-1824
Citations number
24
Categorie Soggetti
Plant Sciences
Journal title
Phytochemistry → ACNP
ISSN journal
00319422
Volume
40
Issue
6
Year of publication
1995
Pages
1821 - 1824
Database
ISI
SICI code
0031-9422(1995)40:6<1821:SSOVAB>2.0.ZU;2-1
Abstract
SCF-CI-dipole velocity MO calculations have shown that the bisignate c ircular dichroic curves of vinblastine/vincristine alkaloids at ca 210 and 220-230 nm are due to exciton coupling between the indoline and i ndole moieties. Furthermore, a combination of X-ray crystal structure data with MM2 local energy minimization provides a convenient means fo r estimation of the preferred solution conformation.