Rl. Arden et al., SURVIVAL OF COMPOSITE CHONDROCUTANEOUS GRAFTS BY VESSEL IMPLANTATION - A STUDY IN THE RABBIT EAR MODEL, The Laryngoscope, 105(12), 1995, pp. 1326-1333
Composite chondrocutaneous graft reconstruction or reattachment has li
mited applicability, is traditionally restricted to small segmental lo
sses, and is dependent on the status of the recipient bed and graft pe
riphery for successful revascularization, Surgical enhancement of comp
osite graft survival was experimentally investigated in the rabbit ear
model through transposition and appositional placement of an adjacent
vascular pedicle. Fluorescein-derived surface-survival determinations
, microangiographic vessel-counting methods, and histologic analysis w
ere used to study the effects of vascular augmentation, pedicle design
variations, and angiogenic substance in sixty 8-cm(2), full-thickness
auricular grafts. A statistically significant survival advantage was
demonstrated for the implanted grafts, without derived benefit from an
giogenic substance, secondary to perivascular angiogenesis from the im
planted pedicle.