SJOGRENS-SYNDROME TERMINATING WITH MULTIPLE-MYELOMA

We describe a patient (49 years old, female) with a more than 7-year h istory of both Sjogren's syndrome (SjS) and benign monoclonal gammopat hy (BMG) of IgG lambda who later developed multiple myeloma (MM). SjS is frequently complicated with malignant lymphoproliferative disorders , especially malignant lymphoma or Waldenstrom's macroglobulinemia. As sociation of SjS with MM seems to be extremely rare, although MG has b een observed frequently in SjS, and there are many reports concerning the association between rheumatoid arthritis and MM.