ANTIPHOSPHOLIPID ANTIBODIES PARTLY ACCOUNT FOR ANTIENDOTHELIAL CELL REACTIVITY

Authors
LETONQUEZE M SALOZHIN KV DUEYMES M NASSONOV EL FRANCES C PIETTE JC YOUINOU P
Citation
M. Letonqueze et al., ANTIPHOSPHOLIPID ANTIBODIES PARTLY ACCOUNT FOR ANTIENDOTHELIAL CELL REACTIVITY, Nouvelle revue francaise d'hematologie, 37, 1995, pp. 61-64
Citations number
16
Categorie Soggetti
Hematology
Journal title
Nouvelle revue francaise d'hematologie → ACNP
ISSN journal
00294810
Volume
37
Year of publication
1995
Supplement
2
Pages
61 - 64
Database
ISI
SICI code
0029-4810(1995)37:<61:AAPAFA>2.0.ZU;2-6
Abstract
Anti-endothelial cell reactivity is partly due to anticardiolipin anti bodies (aCLA) since: 1) the two types of antibody are present in patie nts with connective tissue diseases and CL-binding monoclonal antibodi es bind to endothelial cell; 2) anionic phospholipids are detectable i n the outer face of the EC membrane lipid bilayer and an anti-beta(2)- glycoprotein I (beta(2)-GPI) monoclonal antibody recognizes EC and 3) the binding of aCLA to EC and its functional affinity are dependent on the presence of beta(2)-GPI.