THE EFFECT OF HEPATOCYTE GROWTH-FACTOR SCATTER FACTOR ON HUMAN HAIR FOLLICLE GROWTH

Authors
JINDO T TSUBOI R IMAI R TAKAMORI K RUBIN JS OGAWA H
Citation
T. Jindo et al., THE EFFECT OF HEPATOCYTE GROWTH-FACTOR SCATTER FACTOR ON HUMAN HAIR FOLLICLE GROWTH, Journal of dermatological science, 10(3), 1995, pp. 229-232
Citations number
19
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
Journal of dermatological science → ACNP
ISSN journal
09231811
Volume
10
Issue
3
Year of publication
1995
Pages
229 - 232
Database
ISI
SICI code
0923-1811(1995)10:3<229:TEOHGS>2.0.ZU;2-O
Abstract
The effect of hepatocyte growth factor/scatter factor (HGF/SF) on huma n hair follicle growth was examined using: a serum-free organ culture system. The DNA synthesis in human hair follicles and elongation of th e hair shaft were measured subsequent to the follicle isolation and cu lture at 31 degrees C in 95%, O-2-5%, CO2 for 72 h. Results showed tha t HGF/SF significantly increased H-3-thymidine (P < 0.001) incorporati on and hair follicle length (P < 0.05). The effect of HGF/SF was dose- dependent with a maximal stimulation at 10 ng/ml.