The type I CaM-sensitive adenylyl cyclase is in a position to integrat
e signals from multiple inputs, consistent with the requirements for m
ediating long term potentiation (LTP). Biochemical and genetic evidenc
e supports the idea that this enzyme plays an important role in LTP. H
owever, more work is needed before we will be certain of the role that
CaM-sensitive adenylyl cyclases play in LTP.