REGULATION OF ADENYLYL-CYCLASE IN LTP

Authors
ROBERSON ED SWEATT JD
Citation
Ed. Roberson et Jd. Sweatt, REGULATION OF ADENYLYL-CYCLASE IN LTP, Behavioral and brain sciences, 18(3), 1995, pp. 485-486
Citations number
16
Categorie Soggetti
Psychology,Neurosciences,"Behavioral Sciences
Journal title
Behavioral and brain sciences → ACNP
ISSN journal
0140525X
Volume
18
Issue
3
Year of publication
1995
Pages
485 - 486
Database
ISI
SICI code
0140-525X(1995)18:3<485:ROAIL>2.0.ZU;2-B
Abstract
Our results on hippocampal long-term potentiation are considered in th e context of Xia et al.'s hypothesis. Whereas the target article propo ses presynaptic PKC involvement in adenylyl cyclase activation by phos phorylation of neuromodulin, we suggest an additional postsynaptic rol e involving RC3/neurogranin. Finally, we examine the possibility that the adenylyl cyclase mutant mouse may display normal learning with a s elective impairment of memory.