There are multiple reports in the literature of vascular erosion in th
e innominate vein or superior vena cava from the use of temporary cent
ral venous catheters. Catheter malposition is likely to precede the de
velopment of superior vena cava perforations, a catastrophic complicat
ion of central venous catheters. Catheter malposition after initial ad
equate placement is a very unusual long-term complication and delayed
recognition of this complication may have disastrous consequences. Sho
uld the catheter change position so the tip is angled toward the sidew
all, the repetitive movement of the catheter tip that occurs with resp
iratory excursion and the cardiac cycle may lead to endothelial injury
and eventual erosion of the vein. These problems are thought to be al
leviated in the patient receiving long-term intravenous therapy by usi
ng a soft Silastic catheter, which may not cause as much damage to the
endothelium of the vein. We report three patients with left-sided lon
g-term indwelling Silastic catheters that had changed position over ti
me who presented with chest pain upon infusion of their total parenter
al nutrition solutions. In each case, chest x-ray revealed that the ti
p of the catheter had migrated and was directed against the sidewall o
f the superior vena cava. In each case, catheter removal and replaceme
nt with a new catheter into the right side (subclavian and jugular sys
tems) led to prompt relief of the patient's symptoms.