Rj. Young et al., SYNTHESIS AND ANTIVIRAL EVALUATION OF ENANTIOMERIC 2',3'-DIDEOXY-2',3'-DIDEOXY-4'-THIONUCLEOSIDES AND 2',3'-DIDEHYDRO-2',3'-DIDEOXY-4'-THIONUCLEOSIDES, Bioorganic & medicinal chemistry letters, 5(22), 1995, pp. 2599-2604
The synthesis and antiviral evaluation of 2',3'-dideoxy and 2',3'-dide
hydro-2',3'-dideoxy 4'-thionucleosides in both enantiomeric series are
described. Enantiomeric -O-silylated-4-hydroxymethyl-4-thiobutyrolact
ones, produced in high yield from chiral glycidols, provided suitable
chiral synthons: phenylselenation of these intermediates resulted in a
nomeric selectivity in nucleobase glycosidations. L-d4-cytidine analog
ues showed marked anti-HBV and anti-HIV activity.