RATIONAL DESIGN, SYNTHESIS, AND X-RAY STRUCTURE OF RENIN INHIBITORS WITH EXTENDED P-1 SIDE-CHAINS

Authors
LEFKER BA HADA WA WRIGHT AS MARTIN WH STOCK IA SCHULTE GK PANDIT J DANLEY DE AMMIRATI MJ SNEDDON SF
Citation
Ba. Lefker et al., RATIONAL DESIGN, SYNTHESIS, AND X-RAY STRUCTURE OF RENIN INHIBITORS WITH EXTENDED P-1 SIDE-CHAINS, Bioorganic & medicinal chemistry letters, 5(22), 1995, pp. 2623-2626
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
22
Year of publication
1995
Pages
2623 - 2626
Database
ISI
SICI code
0960-894X(1995)5:22<2623:RDSAXS>2.0.ZU;2-P
Abstract
Structural information from a complex of a tetrapeptide renin inhibito r, CP-85,339, with human biphenyl sidechain at P1 and glycine at P3 le d to a 160X increase in potency over the analogous phenyl compound. A crystal structure of this compound in complex with recombinant human r enin (rHR) was solved.