SYNTHESIS OF CONFORMATIONALLY-CONSTRAINED STEREOSPECIFIC ANALOGS OF GLUTAMIC-ACID AS ANTAGONISTS OF METABOTROPIC RECEPTORS

Authors
TELLIER F ACHER F BRABET I PIN JP BOCKAERT J AZERAD R
Citation
F. Tellier et al., SYNTHESIS OF CONFORMATIONALLY-CONSTRAINED STEREOSPECIFIC ANALOGS OF GLUTAMIC-ACID AS ANTAGONISTS OF METABOTROPIC RECEPTORS, Bioorganic & medicinal chemistry letters, 5(22), 1995, pp. 2627-2632
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
22
Year of publication
1995
Pages
2627 - 2632
Database
ISI
SICI code
0960-894X(1995)5:22<2627:SOCSAO>2.0.ZU;2-L
Abstract
Rigid analogs of ACPD have been synthesized to mimick different potent ial conformations of ACPD in aqueous solution. One of them, (+/-)-ABHD -I is a competitive antagonist at mGluR1a receptor with a K-B value of 300 mu M.