6,3'-DINITROFLAVONE, A NOVEL HIGH-AFFINITY LIGAND FOR THE BENZODIAZEPINE RECEPTOR WITH POTENT ANXIOLYTIC PROPERTIES

Authors
MARDER M VIOLA H WASOWSKI C WOLFMAN C WATERMAN PG MEDINA JH PALADINI AC
Citation
M. Marder et al., 6,3'-DINITROFLAVONE, A NOVEL HIGH-AFFINITY LIGAND FOR THE BENZODIAZEPINE RECEPTOR WITH POTENT ANXIOLYTIC PROPERTIES, Bioorganic & medicinal chemistry letters, 5(22), 1995, pp. 2717-2720
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
22
Year of publication
1995
Pages
2717 - 2720
Database
ISI
SICI code
0960-894X(1995)5:22<2717:6ANHLF>2.0.ZU;2-E
Abstract
6,3'-Dinitroflavone (2) and 6,4'-dinitroflavone (3), prepared by direc t nitration of flavone (1), were found to be ligands for the benzodiaz epine receptor (BDZ-R). Compound 2, with a K-i= 12 nM, produced potent anxiolytic effects in mice at a dose of 1 mu g/Kg.