9-TETRAHYDRO-3-HYDROXY-1H-1-BENZAZEPINE-2,5-DIONES VIA A DIELS-ALDER REACTION - ANTAGONISTS WITH A NONPLANAR HYDROPHOBIC REGION FOR NMDA RECEPTOR GLYCINE SITES

Authors
GUZIKOWSKI AP HAWKINSON J WEBER E KEANA JFW
Citation
Ap. Guzikowski et al., 9-TETRAHYDRO-3-HYDROXY-1H-1-BENZAZEPINE-2,5-DIONES VIA A DIELS-ALDER REACTION - ANTAGONISTS WITH A NONPLANAR HYDROPHOBIC REGION FOR NMDA RECEPTOR GLYCINE SITES, Bioorganic & medicinal chemistry letters, 5(22), 1995, pp. 2747-2748
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
22
Year of publication
1995
Pages
2747 - 2748
Database
ISI
SICI code
0960-894X(1995)5:22<2747:9VADR>2.0.ZU;2-F
Abstract
Benzazepines 10a, 10b and 12 were prepared via a Diels-Alder reaction of dienes 5a and 5b with 6 followed by a Schmidt reaction on 9a, 9b an d 11 then demethylation. The potencies of 10b and 12 for NMDA receptor glycine sites demonstrate binding site tolerance to antagonists with a non-planar hydrophobic region.