AN INVESTIGATION OF THE ACTIVITIES OF 3-HYDROXYKYNURENINASE AND KYNURENINE AMINOTRANSFERASE IN THE BRAIN IN HUNTINGTONS-DISEASE

Previous reports have indicated abnormalities in the concentrations of metabolites of the tryptophan/kynurenine pathway in the brain in Hunt ington's disease. These have included an increase in 3-hydroxykynureni ne and both increases and decreases in kynurenic acid. The activities of two enzymes involved in the metabolism of these compounds, 3-hydrox ykynureninase and kynurenine aminotransferase, have been determined in post mortem brain tissue taken from Huntington's disease patients and control subjects.