EFFICACY AND TOLERABILITY OF BRODIMOPRIM OD VERSUS NORFLOXACIN BID INTHE TREATMENT OF BACTERIAL URINARY-TRACT INFECTIONS

The efficacy and tolerability of brodimoprim OD versus norfloxacin BID were studied in patients affected by bacterial urinary tract infectio ns. The study was performed in 203 patients divided into two parallel randomized groups orally given either brodimoprim 400 mg OD on the fir st day followed by 200 mg OD for 2 days, or norfloxacin 400 mg BID res pectively. The efficacy of treatment was evaluated by the bacterial cu ltures, tolerability, analysis of signs and symptoms, a complete physi cal examination and from laboratory data. The results showed that brod imoprim and norfloxacin in the majority of patients resulted in a redu ction of fever and symptoms caused by the infective process. Of the 10 3 patients enrolled in the brodimoprim OD group, 99 had a complete cou rse of therapy with a positive outcome. There was only one case of fai led treatment and 3 cases which could not be evaluated because of volu ntary interruption of treatment. Of the 100 patients treated with norf loxacin BID, 94 completed therapy with a positive clinical outcome and there were 4 cases of treatment failure. Thus the efficacy of brodimo prim OD appears comparable to that of norfloxacin BID in the treatment of urinary tract infections.