PEPTIDE MIMICS OF GLYCYLPROLINE AS INHIBITORS OF PROLIDASE

Authors
KUMARAVEL G BOETTCHER BR SHAPIRO MJ PETTER RC
Citation
G. Kumaravel et al., PEPTIDE MIMICS OF GLYCYLPROLINE AS INHIBITORS OF PROLIDASE, Bioorganic & medicinal chemistry letters, 5(23), 1995, pp. 2825-2828
Citations number
32
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
23
Year of publication
1995
Pages
2825 - 2828
Database
ISI
SICI code
0960-894X(1995)5:23<2825:PMOGAI>2.0.ZU;2-W
Abstract
Aminoketone 1, a Psi[CO-CK] dipeptide mimic of glycylproline, is a pot ent, competitive inhibitor (K-i = 270 +/- 24 nM) of porcine kidney pro lidase, a Mn(II)-dependent dipeptidase, whereas the homologous aminoke tone 2 and its non-cyclic analogue delta-amino-levulinic acid, 3, are significantly less inhibitory (K-i approximate to 1 mM).