SERINE-PROTEASE SELECTIVITY OF THE THROMBIN INHIBITOR D-PHE-PRO-AGMATINE AND ITS HOMOLOGS

Authors
WILEY MR CHIRGADZE NY CLAWSON DK CRAFT TJ GIFFORDMOORE DS JONES ND OLKOWSKI JL SCHACHT AL WEIR LC SMITH GF
Citation
Mr. Wiley et al., SERINE-PROTEASE SELECTIVITY OF THE THROMBIN INHIBITOR D-PHE-PRO-AGMATINE AND ITS HOMOLOGS, Bioorganic & medicinal chemistry letters, 5(23), 1995, pp. 2835-2840
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
23
Year of publication
1995
Pages
2835 - 2840
Database
ISI
SICI code
0960-894X(1995)5:23<2835:SSOTTI>2.0.ZU;2-O
Abstract
Analogs of D-Phe Pro-Agmatine were assayed for inhibititory activity v ersus thrombin, trypsin, plasmin, n-tPA and urokinase. The X-ray struc ture of the thrombin/D-Phe-Pro-Agmatineo-crystal revealed that the agm atine and analogous arginals have very similar bound conformations.