NOVEL CYCLIC-PEPTIDES CONTAINING A GAMMA-GLUTAMYL RESIDUE INDUCE IL-1SECRETION FROM HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS

Authors
SHEH L JENG KCG CHEN BL LIN HH
Citation
L. Sheh et al., NOVEL CYCLIC-PEPTIDES CONTAINING A GAMMA-GLUTAMYL RESIDUE INDUCE IL-1SECRETION FROM HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS, Bioorganic & medicinal chemistry letters, 5(23), 1995, pp. 2869-2874
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
23
Year of publication
1995
Pages
2869 - 2874
Database
ISI
SICI code
0960-894X(1995)5:23<2869:NCCAGR>2.0.ZU;2-8
Abstract
Three synthetic cyclic tripeptides, each containing a gamma-glutamyl r esidue were shown to induce the production of interleukin-l (IL-I) fro m human peripheral blood mononuclear cells (PBMC). In addition,the cyc lic peptide cyclo[Glu(Lys-beta-Ala-)-OH] (cG-2) was capable of eliciti ng IL-1 production from PBMC dose-dependently.