SUBSTITUTED 2,4-DIAMINOQUINAZOLINES AND 2,4-DIAMINO-8-ALKYLPURINES ASANTAGONISTS OF THE NEUROKININ-2 (NK2) RECEPTOR

Authors
JACOBS RT MAUGER RC ULATOWSKI TG AHARONY D BUCKNER CK
Citation
Rt. Jacobs et al., SUBSTITUTED 2,4-DIAMINOQUINAZOLINES AND 2,4-DIAMINO-8-ALKYLPURINES ASANTAGONISTS OF THE NEUROKININ-2 (NK2) RECEPTOR, Bioorganic & medicinal chemistry letters, 5(23), 1995, pp. 2879-2884
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
23
Year of publication
1995
Pages
2879 - 2884
Database
ISI
SICI code
0960-894X(1995)5:23<2879:S2A2A>2.0.ZU;2-#
Abstract
Modification of the heterocyclic nucleus of a lead pyrrolopyrimidine ( 1) found to be active as an antagonist at the neurokinin-2 (NK2) recep tor is described. Compounds based on the purine nucleus (3) were found to be particularly interesting, and were modified in the C(2), C(4) a nd C(8) substituents to afford compounds with high potency.