R. Fernandezgomez et al., 2-AMINO DIPHENYLSULFIDES AS NEW INHIBITORS OF TRYPANOTHIONE REDUCTASE, International journal of antimicrobial agents, 6(2), 1995, pp. 111-118
Trypanothione reductase (TR) is the primary enzyme responsible for the
reduction of trypanothione, the analog of glutathione found in trypan
osomatidae. We have discovered a series of diphenylsulfides which are
potent inhibitors of TR and have no activity on mammalian glutathione
reductase. These compounds are also active in vitro on various stages
of the parasite. Although structurally related to phenothiazines, whic
h are known to be TR inhibitors, these compounds are devoided of any n
euroleptic activity, making them attractive leads to develop specific
and non toxic anti-chagasic drugs.