FOCAL CHANGES OF SINUS HISTIOCYTOSIS WITH MASSIVE LYMPHADENOPATHY (ROSAI DORFMAN DISEASE) ASSOCIATED WITH NODULAR LYMPHOCYTE PREDOMINANT HODGKINS-DISEASE/

Sinus histiocytosis with massive lymphadenopathy (SHML/Rosai-Dorfman d isease) has, on rare occasions been identified as an isolated phenomen on in lymph nodes affected by malignant lymphomas, The Registry includ es four cases of SHML in patients with non-Hodgkin's lymphomas and one with multiple myeloma, SHML has more recently been recorded as a foca l finding in lymph nodes involved by Hodgkin's disease of the mixed ce llularity type. We report two patients presenting with lymphadenopathy caused by involvement by nodular lymphocyte predominant Hodgkin's dis ease with focal changes of SHML, an association not previously recorde d in the literature, Responsiveness of the histiocytic cells of SHML t o B-cell derived cytokines is postulated as a mechanism for this pheno menon, an hypothesis previously raised in regard to the association of focal Langerhans cell histiocytosis with Hodgkin's disease and with n on-Hodgkin's lymphomas. Copyright (C) 1995 by W.B. Saunders Company