A. Poso et al., AN EMPIRICAL AND THEORETICAL-STUDY ON MECHANISMS OF MUTAGENIC ACTIVITY OF HYDRAZINE COMPOUNDS, Mutation research, 332(1-2), 1995, pp. 63-71
Hydrazine compounds are important industrial and laboratory chemicals.
Many,of them are carcinogenic ill animal tests. Although the carcinog
enicity is well established, the results of mutagenicity tests perform
ed an alkylhydrazines vary greatly in different Studies. In an attempt
to clarify the situation we have applied Salmonella typhimurium TA102
tests to hydrazine and its mono- and dimethyl derivatives. These comp
ounds were also tested by an Escherichia coli DNA repair-assay. The re
sults of the repair tests indicate that unsymmetrically alkylated hydr
azines can cause DNA-lesions which are lethal in repair-deficient stra
ins. Finally QSAR (Quantitative Structure Activity Relationships) was
used td develop La model to describe the genotoxic mechanism of hydraz
ine compounds, taking advantage of the results of previous mutagenicit
y studies. Energy of the lowest unoccupied molecular orbital together
with. octanol-water partition coefficient explains nearly completely t
he mutagenic activity of alkylated hydrazine compounds included in the
analysis. The mutagenic activity of unsubstituted hydrazine is appare
ntly based on different mechanisms.