H. Okazawa et al., DELAYED DATA-ACQUISITION FOR OPTIMAL PET ACTIVATION STUDIES WITH OXYGEN-15-WATER IN CEREBRAL ARTERIOVENOUS MALFORMATION, The Journal of nuclear medicine, 36(12), 1995, pp. 2149-2153
In the clinical application of activation PET studies with O-15-water,
optimal PET images are required when the high activity of a nearby le
sion might affect the activated area. Methods: To determine the optima
l time for data acquisition of PET images, we performed serial dynamic
PET measurements in five patients with cerebral arteriovenous malform
ation (AVM). All AVMs were closest to the motor cortices, and the acti
vation task was opponent finger movement contralateral to the AVM. Act
ivation PET and MR images were coregisterated for localization of acti
vated foci. Results: Time-activity curves of the nidus and normal cort
ex from the dynamic PET data demonstrated a discrepancy in peak time a
nd significant radioactivity increase in the nidus during the early ph
ase. Elimination of the initial PET data provided better contrast in a
ctivated foci without affecting the calculated cerebral blood flow of
other areas. Conclusion: Delayed data acquisition can avoid interferen
ce of the AVM nidus with the activated area.