SELECTIVE FILTRATION - A PHLEBOTOMY FOR SICKLE-CELL THERAPY

Authors
NUSBAUM NJ
Citation
Nj. Nusbaum, SELECTIVE FILTRATION - A PHLEBOTOMY FOR SICKLE-CELL THERAPY, The American journal of the medical sciences, 310(6), 1995, pp. 264-266
Citations number
12
Categorie Soggetti
Medicine, General & Internal
Journal title
The American journal of the medical sciences → ACNP
ISSN journal
00029629
Volume
310
Issue
6
Year of publication
1995
Pages
264 - 266
Database
ISI
SICI code
0002-9629(1995)310:6<264:SF-APF>2.0.ZU;2-G
Abstract
The molecular defect in sickle cell disease is an error in the coding for hemoglobin synthesis. All of a patient's erythrocyte precursors sh are the genetic defect, but the patient's circulating erythrocytes are heterogenous in their degree of deformability. Periodic removal, by s elective filtration, of the least deformable of the circulating erythr ocytes might prove of clinical benefit.