RENAL EFFECTS OF DIETARY SUPPLEMENTATION WITH FISH-OIL IN CYCLOSPORINE-TREATED LIVER-TRANSPLANT RECIPIENTS

Nephrotoxicity is the main untoward effect of cyclosporine (CsA) treat ment. Experimental and clinical data suggest that dietary supplementat ion with fish oil may lessen cyclosporine nephrotoxicity, possibly by lowering renal thromboxane (Tx) production. We have studied the renal effects of a daily supplementation for 2 months of 12 g fish oil (18% C20:5 n-3 eicosapentaenoic acid [EPA] and 12% C22:6 n-3 docosahexanoic acid [DHA]) in a placebo-controlled (12 g corn oil), prospective, ran domized, double-blind study of stable CsA-treated liver transplant rec ipients. Thirteen patients ingested corn oil capsules and 13 fish oil. Compliance with dietary regimen was confirmed by fatty acid chromatog raphy that showed increased plasma concentrations of EPA (from 0.4 +/- 0.02% to 4.6 +/- 0.5%, P < .0001) and DHA (from 1.8 +/- 0.2% to 3.9 /- 0.1%, P < .0001) in the fish oil group and increased plasma concent ration of Linoleic acid (C18:2 n-6) in the corn oil group (from 25 +/- 2% to 28.4 +/- 2%, P < .001). At the end of the 2 months of the study , in the fish oil group the effective renal plasma now increased by 22 % (P = .012), the glomerular filtration rate increased by 33% (P = .05 7), the renal blood now increased by 17% (P = .024), and the calculate d total renal vascular resistances decreased by 20% (P = .034). In con trast, none of these parameters changed in the corn oil group. The ren al functional reserve determined during L-arginine infusion, plasma re nin activity (PRA), and plasma aldosterone (PA) remained unchanged dur ing the study in either group. The urine excretion of Tx Bz decreased from 707 +/- 192 to 276 +/- 76 pg/hr (P = .013) in fish oil group, whe reas it increased hom 428 +/- 195 to 870 +/- 310 pg/hr (P = .016) in c orn oil group, In conclusion, 2 months of diet supplementation with fi sh oil in stable CsA-treated liver transplant recipients was associate d with significant improvement of renal hemodynamics and with signific ant reduction of the renal production of TxB(2).