G. Blazso et M. Gabor, EFFECTS OF PROSTAGLANDIN ANTAGONIST PHLORETIN DERIVATIVES ON MOUSE EAR EDEMA INDUCED WITH DIFFERENT SKIN IRRITANTS, Prostaglandins, 50(3), 1995, pp. 161-168
Edema was induced in one ear of male mice of the CFLP strain with solu
tions of different skin irritants (croton oil 10 mu L/35 mu g, dithran
ol 20 mu L/30 mu g, capsaicin 10 mu L/40 mu g or arachidonic acid to 1
0 mu L/2 mg per ear). Edema, determined by the edema-disk gravimetric
technique, was inhibited in a dose-dependent manner by the intraperito
neally administered prostaglandin antagonists polyphloretin phosphate
(PPP) or di-4-phloretin phosphate (DPP). With croton oil-induced mouse
ear edema, DPP 10 mg/kg caused a 38% inhibition, PPP 25 mg/kg a 33% i
nhibition. With dithranol-induced edema DPP 0.5 mg/kg caused a 57% inh
ibition, while PPP 25 mg/kg was needed to exert a similar effect. Dose
s of DPP and PPP needed to cause a >40% inhibition of edema were 10 mg
/kg and 25 mg/kg, respectively for capsaicin, and 25 mg/kg and 200 mg/
kg for arachidonic acid. The inhibition of the ear edema by the phlore
tin derivatives was: dithranol > croton oil > capsaicin > arachidonic
acid. This probably reflects the different contributions of prostaglan
dins to the inflammation.