STRIATAL DOPAMINERGIC DENERVATION IN PALLIDOPYRAMIDAL DISEASE DEMONSTRATED, BY POSITRON EMISSION TOMOGRAPHY

Pallidopyramidal disease is a rare disease of young patients in which they manifest a parkinsonian syndrome and pyramidal signs. Pallidopyra midal disease has been attributed to a degeneration of the pallidum an d the pyramidal tract, although only 1 patient has been studied postmo rtem. In the present report, [F-18]fluorodopa positron emission tomogr aphy in 2 patients showed a marked dopaminergic denervation of the str iatum, suggesting that this disease corresponds more to a nigropallido pyramidal dysfunction.