This article details flight results from the Principal Investigator (P
I)-in-a-Box project. The project is an attempt to understand the issue
s involved in building automated real-time advisory systems to improve
the conduct of science in remote laboratory settings. This ir an impo
rtant problem, as examples of these situations can be found throughout
aerospace. A knowledge-bared approach is used to facilitate real-time
reactions to experiment data as they are collected by a competent, bu
t not expert, operator The system was flown on the Space Shuttle in Oc
tober 1993. The PI-in-a-Box system was able to outperform humans in a
variety of science-related tasks; including data integrity assurance,
data analysis, and scientific model validation.