Ib. Rosenwald, GROWTH FACTOR-INDEPENDENT EXPRESSION OF THE GENE ENCODING EUKARYOTIC TRANSLATION INITIATION-FACTOR 4E IN TRANSFORMED-CELL LINES, Cancer letters, 98(1), 1995, pp. 77-82
Activation of protein synthesis is necessary for the transition of cel
ls from quiescence to proliferation, while withdrawal of growth factor
s leads to decrease in protein synthesis and transition of normal cell
s into the resting period. It is shown in this paper that serum growth
factors are required for activation of expression of gene encoding tr
anslation initiation factor 4E (eIF-4E) in non-transformed NIH 3T3 and
Rat-1 fibroblasts but this requirement is lost in C6 glioblastoma, A4
31 carcinoma and N-myc transformed Rat-1 cells. These data raise the p
ossibility that neoplastic transformation leads to growth factor-indep
endent expression of eIF-4E, thus facilitating continuous growth and r
eplication of transformed cells.