RENAL PATHOLOGY AFTER ARTERIAL Y-90 MICROSPHERE ADMINISTRATION IN PIGS - A MODEL FOR SUPERSELECTIVE RADIOEMBOLIZATION THERAPY

RATIONALE AND OBJECTIVES. To test the selectivity of tissuedamage in r adioembolization, the authors performed an experimental study using su perselective administration of yttrium-90 particles to deliver up to 1 00 Gy to the porcine kidney. Patterns and severity of damage in test o rgans were compared with controls, and the feasibility of this model i s discussed. METHODS. Eight sows were included in the study, Bio-Rex 7 0 particles were applied via selective catheterization of the renal ar tery. Four pigs received inactive particles and four pigs received act ive particles. Organ distribution and shunting of yttrium-90 were dete rmined, and kidney damage patterns were histologically analyzed. RESUL TS AND CONCLUSIONS. The model demonstrates that yttrium-90-labeled res in particles can superselectively be applied. Retention of beta activi ty in the target organ was more than 95%. In addition to tissue shrink age from mechanical obstruction, considerable damage ensued mainly by radiation-induced arterial necrosis and arteritis.