DOES THE HEARTS HORMONE, ANP, HELP IN CONGESTIVE-HEART-FAILURE

Authors
WINAVER J HOFFMAN A ABASSI Z HARAMATI A
Citation
J. Winaver et al., DOES THE HEARTS HORMONE, ANP, HELP IN CONGESTIVE-HEART-FAILURE, News in physiological sciences, 10, 1995, pp. 247-253
Citations number
15
Categorie Soggetti
Physiology
Journal title
News in physiological sciences → ACNP
ISSN journal
08861714
Volume
10
Year of publication
1995
Pages
247 - 253
Database
ISI
SICI code
0886-1714(1995)10:<247:DTHHAH>2.0.ZU;2-U
Abstract
In congestive heart failure, increased secretion of atrial natriuretic peptide (ANP) is an important compensatory mechanism that unloads the failing heart and promotes renal salt and water excretion. However, a ctivation of opposing sodium-retaining factors, particularly the renin -angiotensin system, reduces renal responsiveness to ANP and shifts th e cardiovascular system to a state of decompensation.