REGULATION OF NA-K+ PUMP ACTIVITY - PATHWAYS BETWEEN RECEPTORS AND EFFECTORS()

Short-term regulation of membrane Na+-K+-ATPase activity is achieved b y complex networks of receptor-media fed intracellular signals. Such r egulatory pathways include activation of cyclic AMP-dependent protein kinase or protein kinase C and involve reversible phosphorylation of t he catalytic (alpha) subunit of the enzyme directly, of additional med iators like eicosanoids and the actin cytoskeleton, or both.