A PRACTICAL ROUTE TO CHIRAL PHENYLALANINE VIA THE CONDENSATION OF KETO ACIDS WITH AMIDES AND ASYMMETRIC HYDROGENATION

Authors
CHAU TY TSUI JH LIN CC CHAN ASC
Citation
Ty. Chau et al., A PRACTICAL ROUTE TO CHIRAL PHENYLALANINE VIA THE CONDENSATION OF KETO ACIDS WITH AMIDES AND ASYMMETRIC HYDROGENATION, Journal of the Chinese Chemical Society, 42(6), 1995, pp. 977-980
Citations number
10
Categorie Soggetti
Chemistry
Journal title
Journal of the Chinese Chemical Society → ACNP
ISSN journal
00094536
Volume
42
Issue
6
Year of publication
1995
Pages
977 - 980
Database
ISI
SICI code
0009-4536(1995)42:6<977:APRTCP>2.0.ZU;2-I
Abstract
The condensation of beta-phenylpyruvic acid with amides gave olefinic intermediates in good yields (75-80%). The asymmetric catalytic hydrog enation of alpha-acetamidocinnamic acid with high enantioselectivity i s described.