THERAPEUTIC EFFECTS AND SIDE-EFFECTS IN PATIENTS WITH MAJOR DEPRESSION TREATED WITH SULPIRIDE ONCE-A-DAY

1. The effects of once a day dose of sulpiride efficacy and safety was evaluated in patients with major depressive disorder. The patients re ceived sulpiride once a day in the morning or in the evening. 2. There were no significant differences between two groups in the mean measur es of efficacy. Side effects were rare and all of a mild degree. The m ost common side effects were sedation, constipation, and dryness of mo uth. 3. Out of regard for the administrative and psychological advanta ge of the once a day dosage this form should be preferred in the treat ment of major depression.