CARBON-DIOXIDE LASER MINICONIZATION FOR TREATMENT OF HUMAN PAPILLOMAVIRUS INFECTION ASSOCIATED WITH CERVICAL INTRAEPITHELIAL NEOPLASIA

Background. The effect of the carbon dioxide laser miniconization for treatment of cervical intraepithelial neoplasia with concomitant human papillomavirus infection was evaluated. Material and methods. One hun dred and eighteen women with cytologically proven cervical intraepithe lial neoplasia stage 1 and/or 2 were investigated with repeat vaginal smear, colposcopy and human papillomavirus DNA sampling. Seventy-five out of 118 women were subjected to laser miniconization or punch biops y and cervical curettage. Results. Out of 118 patients 37 proved to ha ve positive human papillomavirus DNA with one or more oncogenic types (31.4%). Of these, 32 women were miniconized and five subjected to pun ch biopsy or cervical curettage. On the first follow-up after miniconi zation all 32 patients were HPV negative. With follow-up up to five ye ars no recurrences of HPV or dysplasia were seen. Conclusion. A minico nization procedure with carbon dioxide laser for treatment of cervical intraepithelial neoplasia proved useful also for simultaneous therapy of concomitant human papillomavirus infection of the uterine cervix.