Pharmacologists are often required to analyse nonlinear experimental e
ffects by fitting the data to defined theoretical models, This may req
uire a specialized computer program capable of performing nonlinear re
gression analysis, which can prove costly given the variety of pharmac
ological research. Here, Wayne Bowen and Jeff Jerman describe a generi
c method of performing nonlinear regression using spreadsheet applicat
ions, and demonstrate how this approach can be used to create automate
d systems of data analysis.