ALLELE DOSES OF APOLIPOPROTEIN-E TYPE EPSILON-4 IN SPORADIC LATE-ONSET ALZHEIMERS-DISEASE

Authors
LUCOTTE G AOUIZERATE A GERARD N TURPIN JC LANDAIS P
Citation
G. Lucotte et al., ALLELE DOSES OF APOLIPOPROTEIN-E TYPE EPSILON-4 IN SPORADIC LATE-ONSET ALZHEIMERS-DISEASE, American journal of medical genetics, 60(6), 1995, pp. 566-569
Citations number
26
Categorie Soggetti
Genetics & Heredity
Journal title
American journal of medical genetics → ACNP
ISSN journal
01487299
Volume
60
Issue
6
Year of publication
1995
Pages
566 - 569
Database
ISI
SICI code
0148-7299(1995)60:6<566:ADOATE>2.0.ZU;2-T
Abstract
Apoliprotein E, type epsilon 4 allele (ApoE-epsilon 4) is associated w ith late-onset sporadic Alzheimer's disease (AD). We have found that t he cumulative probability of remaining unaffected over time decreases for each dose of ApoE-epsilon 4 in sporadic, late-onset French AD. The effect of genotypes on age at onset of AD was analyzed using the prod uct limit method, to compare unaffected groups during aging. (C) 1995 Wiley-Liss, Inc.