EXAGGERATED CARDIOVASCULAR AND BEHAVIORAL NOCICEPTIVE RESPONSES TO SUBCUTANEOUS FORMALIN IN THE SPONTANEOUSLY HYPERTENSIVE RAT

Authors
TAYLOR BK PETERSON MA BASBAUM AI
Citation
Bk. Taylor et al., EXAGGERATED CARDIOVASCULAR AND BEHAVIORAL NOCICEPTIVE RESPONSES TO SUBCUTANEOUS FORMALIN IN THE SPONTANEOUSLY HYPERTENSIVE RAT, Neuroscience letters, 201(1), 1995, pp. 9-12
Citations number
25
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
201
Issue
1
Year of publication
1995
Pages
9 - 12
Database
ISI
SICI code
0304-3940(1995)201:1<9:ECABNR>2.0.ZU;2-V
Abstract
Spontaneously hypertensive rats (SHRs) are typically less responsive t o phasic noxious stimuli than are their normotensive controls. Here, w e used the formalin test to compare behavioral and cardiovascular resp onses to persistent noxious stimuli. Hindpaw formalin injection produc ed exaggerated flinching, arterial pressure and heart rate responses i n SHRs, suggesting that abnormalities in blood pressure control system s increase nociceptive responses to persistent noxious stimuli.