DIFFERENTIAL DISTRIBUTION OF HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINSIN RAT-TISSUES

Heterogeneous nuclear ribonucleoproteins bind to RNA as long as it is transcribed. Since their binding can be sequence-specific, it has been suggested that their expression in different tissues could vary depen ding on the specific mRNA processing requirements. In order to better establish this possibility we studied the presence of the heterogeneou s nuclear ribonucleoproteins Al, A2/B1, C and D in the cell nuclei of different rat tissues by one- and two-dimensional immunoblotting. We f ound that these proteins were heterogeneously distributed among tissue s and that they were found in different proportions. (C) 1995 Academic Press, Inc.